Peptides, explained
without the noise.
What each compound actually is, how it was dosed in the research, and what the data shows. No recommendations — just organised information.
What Happens After the PCAC Vote
A recommendation is the first of four stages, and the other three have no deadline. What has to happen before a pharmacy may compound any of these peptides.
Why Emideltide Was the One Rejected
Six peptides went to the committee and came back recommended. The seventh did not. What separated it is more informative than the vote itself.
RegulationIs Compounded Tirzepatide Still Legal?
Tirzepatide moved before semaglutide, on a clause most summaries drop. The dates, the litigation still running, and why one date is later than usually quoted.
GeneralWhat Peptide Cycling Is Based On
Eight weeks on, four off. The advice is everywhere and the derivation is nowhere. Where the idea actually came from, and what the approved drugs do instead.
GeneralHow Long Do Reconstituted Peptides Last?
An approved product has an in-use period because somebody ran the stability study. For most peptides nobody did, and the numbers online come from elsewhere.
GeneralSubcutaneous or Intramuscular?
The route on a label is not a suggestion about comfort. It is the route the pharmacokinetics were measured in, and changing it changes what the dose data means.
RegulationIs Tesamorelin FDA Approved?
Yes in the United States, for one narrow indication almost nobody quotes. No in the EU, where the application was withdrawn in 2012. The distinction matters.
RegulationAre Peptides Legal in the EU and Bulgaria?
EU law requires a marketing authorisation before a medicinal product is placed on the market. What that means for unapproved peptides, and for Bulgaria.
RegulationIs Compounded Semaglutide Still Legal?
The shortage ended in February 2025 and the grace periods closed that spring. What the FDA position actually permits now, and the rule almost nobody quotes.
RegulationWhat the July 2026 FDA Peptide Vote Did
Six peptides recommended, one rejected, and nothing legal to compound yet. The tallies, the April reclassification behind it, and what still has to happen.
RegulationWhich Peptides Are Actually Approved?
A status table for every compound on this site: approved as a medicine or not, whether US pharmacies may compound it, and where the anti-doping rules land.
EpitalonIs Epitalon Approved? Where the Evidence Ends
Epitalon holds no marketing authorisation and has no completed human trial. What the telomerase studies actually tested, and why the evidence base is so narrow.
KPVIs KPV Approved Anywhere? What the Data Say
KPV holds no marketing authorisation in any jurisdiction and every study behind it is preclinical. What the murine colitis work shows, and why the gut.
MOTS-cIs MOTS-c Approved? What the Evidence Shows
MOTS-c has no marketing authorisation anywhere and its human data are observational. What the 2015 discovery paper found about mitochondrial DNA and AMPK.
GeneralRunning a Peptide Protocol: The Parts
A protocol is five separate problems people treat as one: evidence, frequency, concentration, stability and site. A map of each, and where they connect.
SemaxIs Semax Approved? Russia Yes, EU and US No
Semax is a registered medicine in Russia and unapproved everywhere else — neither the EMA nor the FDA has assessed it. What the research actually shows.
TB-500Is TB-500 Banned? WADA and FDA Status
TB-500 is prohibited in sport at all times and approved as a medicine nowhere. It is also not thymosin beta-4 — analysis found a short synthetic fragment.
BPC-157Is BPC-157 Legal? FDA and WADA Status
BPC-157 is approved as a medicine nowhere and banned in sport at all times. What the July 2026 FDA advisory vote changed, and what it did not.
GeneralInjection Site Rotation and Lipohypertrophy
What lipohypertrophy is, why injection guidance insists on rotating sites, and what the FITTER recommendations say about spacing, needle reuse and inspection.
GeneralPeptide Half-Life: Why Schedules Differ
Why some peptides are injected daily and others weekly — DPP-4 degradation, albumin binding, and what half-life means for steady state and a missed dose.
GeneralReconstitution and Concentration: The Arithmetic
What reconstitution does to a lyophilised peptide, why concentration is the only number that matters, and how mg, ml and syringe units relate to each other.
SemaglutideSemaglutide: What It Is and How It Works
What semaglutide is, how it acts on the GLP-1 receptor, and what the STEP and SELECT trials found about body weight and cardiovascular outcomes.
GeneralPeptide Storage: What Actually Degrades Them
Why peptides are fragile molecules, what breaks them down — heat, light, freeze-thaw cycles and agitation — and what the official labelling says.
TirzepatideTirzepatide: What It Is and How It Works
What tirzepatide is, how it activates the GIP and GLP-1 receptors at the same time, and what the SURPASS and SURMOUNT trials actually found.